We’re building tools for the clinical and research work here at the BC CfE. If you’d like to help stop HIV, look for open positions at the CfE careers page.
If you’d like to know more about our work, two of our main projects are open source: MiCall and Kive. You can also visit the main BC CfE page.
Here are some of the lab’s research papers:
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Automating HIV Drug Resistance Genotyping with RECall, a Freely Accessible Sequence Analysis Tool Conan K. Woods, Chanson J. Brumme, Tommy F. Liu, Celia K. S. Chui, Anna L. Chu, Brian Wynhoven, Tom A. Hall, Christina Trevino, Robert W. Shafer, P. Richard Harrigan Journal of Clinical Microbiology May 2012 DOI: 10.1128/JCM.06689-11
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Phylogenetic approach to recover integration dates of latent HIV sequences within-host Bradley R. Jones, Natalie N. Kinloch, Joshua Horacsek, Bruce Ganase, Marianne Harris, P. Richard Harrigan, R. Brad Jones, Mark A. Brockman, Jeffrey B. Joy, Art F. Y. Poon, Zabrina L. Brumme Proceedings of the National Academy of Sciences Sep 2018 DOI: 10.1073/pnas.1802028115
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A systematic, deep sequencing-based methodology for identification of mixed-genotype hepatitis C virus infections Olmstead, Andrea D; Montoya, Vincent; Chui, Celia K; Dong, Winnie; Joy, Jeffrey B; Tai, Vera; Poon, Art F Y; Nguyen, Thuy; Brumme, Chanson J; Martinello, Marianne; Matthews, Gail V; Richard Harrigan, P; Dore, Gregory J; Applegate, Tanya L; Grebely, Jason; Howe, Anita Y M Infection, Genetics and Evolution Apr 2019 DOI: 10.1016/j.meegid.2019.01.016
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The global origins of resistance-associated variants in the non-structural proteins 5A and 5B of the hepatitis C virus Bradley R Jones, Anita Y M Howe, P Richard Harrigan, Jeffrey B Joy Virus Evolution Jan 2018 DOI: 10.1093/ve/vex041
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The spread of hepatitis C virus genotype 1a in North America: a retrospective phylogenetic study Joy, Jeffrey B; McCloskey, Rosemary M; Nguyen, Thuy; Liang, Richard H; Khudyakov, Yury; Olmstead, Andrea; Krajden, Mel; Ward, John W; Harrigan, P Richard; Montaner, Julio S G; Poon, Art F Y The Lancet. Infectious Diseases Jun 2016 DOI: 10.1016/s1473-3099(16)00124-9
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Ancestral Reconstruction Joy JB, Liang RH, McCloskey RM, Nguyen T, Poon AFY PLoS Comput Biol Jul 2016 DOI: 10.1371/journal.pcbi.1004763